• Produced principally by Pineal Gland. Small amount is secreted by GastroIntestinal Tract and Skin.
  • Daily estimated secretion is 30-100 mcg.
  • Highest level of Melatonin are observed at night and are due to an intense production by Pineal gland during sleep.
  • The lowest level of Melatonin are found during the day. The day time secretion is mainly by the Gastrointestinal Tract and Skin.
  • Melatonin levels decrease with Aging.
  • Melatonin Induces Sleep.
  • Melatonin shortens the time to fall asleep.
  • Melatonin has no action on deep sleep and REM.
  • At night, Melatonin induces profound relaxation of nerves and muscles, which makes the sleep better.
  • Melatonin acts as an antispasmodic for the intestinal tract, relaxing it when it is contracted and tensed.
  • Melatonin protects against free radicals by its antioxidant properties.
  • Melatonin has Antiaging properties.
  • Melatonin boosts Immune functions.
  • Melatonin helps in setting the pace for circadian rhythms such as sleep-wake, temperature and hormones cycles.
  • Melatonin prevents against Jet-Lag.
  • Melatonin can increase the serum levels of Growth Hormone.
  • Melatonin increases the conversion of T4 to T3.
  • Melatonin calms down excessive cortisol activity.

Indications For Melatonin Replacement

  • Circadian Rhythm disorders like JET-LAG.
  • Stress
  • Mood disorders
  • CVA
  • Sleep disorders
  • Immune disorders
  • Component of Menopause HRT
  • Component of Andropause HRT
  • Component of Somatopause HRT
  • Component of Adrenopause HRT
  • Age associated mental decline
  • As anti-oxidant
  • As Immunity Enhancer in various Immunodeficiency states
  • Fibromyalgia
  • Skin Aging
  • Supportive therapy in anti-cancer management
  • Supportive therapy in Alzheimer's disease


  • Test yourself for Melatonin Deficiency (Both Men & Women)

    Test yourself for Melatonin Deficiency (Both Men & Women)

  • Few recommendations by Dr. Deepak Anjana V. Chaturvedi to remember before going for stem cells based therapies

    • Stem cells based therapies have the potential to be a great futuristic medicine.
    • The effects of Stem Cells based therapies are yet to be proven.
    • Go autologous first.
    • Don't pay very hefty amounts for the same.
    • Don't expect miracles but stay optimistic.
    • Evaluate yourself thoroughly before going ahead with it.
    • Don't fall prey to tall claims made by the therapy providers.
    • Don't leave your ongoing treatment (medicines etc) without consulting your doctor.
    • Everything has a potential to give unwanted effects or to get fail. Please stay prepared for the same.

  • Dr. Deepak Anjana V. Chaturvedi's view on Diet

    • 1. No fixed rules about eating behavior.
    • 2. Living long (longevity), Living healthy (wellness), Improved quality of life index (Antiaging) and living comfortably with one or more disability and disease are different entities.
    • 3. Every condition mentioned in point no.2 needs different dietary framework.
    • 4. Affordability and availability are other issues in practical life.
    • 5. Religious and cultural factors affect human eating behavior very much.

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