• Daily secretion of Estradiol in young (18-30 years of age), healthy women is 60-200 mcg a day depending on the phase of the menstrual cycle (with greater production in the second half of the cycle).
  • Intensive prolonged physical activity, such as sexual intercourse and long distance running, use up the sex hormones and may thereby reduce the levels of female hormones.
  • Intense emotional stress can inhibit the secretion of estrogen.
  • High protein and/or saturated fat intake increases estrogen production.
  • Eating sugar, and fibers can reduce female sex hormone levels.
  • Women are born with 1-2 million undeveloped eggs in their ovaries. When women reach puberty and start menstruating , only about 300,000 immature egg cells, or follicles remain, of which an average 600 egg cels die per month and are not replaced.
  • No good egg remains at the time of menopause and since the eggs are the principal producers of female hormones, this explains why all women become hormone deficient over time.
  • Estradiol feminize the body.
  • Estradiol shapes the female body, enlarges breasts and pelvis, redden the skin, causes proliferation of endometrium in the uterus and thus makes menstruation possible.
  • Estradiol causes vaginal lubrication, healthy libido, the female voice, and initiates ovulation.
  • Estrogens are responsible for the rapid growth of the long bones during puberty and also influence psychological and emotional behaviour.
  • Estrogens stimulate the sympathetic nervous system and in this way increase alertness. Unopposed estrogen can make a woman very nervous.
  • Estradiol plays an important role in cognition and brain health in both sexes.
  • Estradiol plays an important role in male libido.
  • Estradiol plays cardio protective role in menstruating women.
  • Estradiol replacement prevents against Osteoporosis and Colorectal cancer in menopausal women.
  • Estriol's main role is to thicken and humidify the mucous membranes of vagina, bladder and eyes, making them resistant to infection. It has minimal effects on uterine endometrium and Breast.

Indications For Estrogen Replacement Therapy

  • Estrogen deficiency states.
  • Primary ovarian failure.
  • Female hypogonadism.
  • Menopause HRT.
  • Menopausal vasomotor symptoms like hot flushes.
  • Temporary menstrual irregularities.
  • Low libido.
  • Dyspareunia in women.
  • Micromastia.
  • Endometriosis.
  • Habitual abortion.
  • Infertility.
  • Premenstrual depression and fatigue.
  • Osteoporosis.
  • Prostate carcinoma.
  • Female hirsutism.
  • Acne in females.
  • Senile vaginitis, urethritis, cystitis, epistaxis and atrophic rhinitis
  • Male hypersexuality.
  • Male to Female gender conversion.

Questionnaires

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